Academic & Service Profile

Innovation & Research

Photo Telephone Hearing ScreeningLynne’s research focuses recently have been in hearing loss, novel biomedical devices, trachea airways, allergic rhinitis and health service delivery and public health. She recently completed a study on telephone administered hearing screening tests for the public. Currently, she is continuing with research grants for a hand-held device to insert grommet tubes for glue ears in the clinic, for bioabsorbable grommet tubes that self destruct after a few months, and new hearing service delivery method via minivans for the community.

Lynne has published consistently in peer-reviewed scientific journals, and is often invited to share her work at regional and international research conferences. She worked with Health Promotion Board MOH as lead for the Clinical Practice Guidelines for Rhinosinusitis and Functional Screening for Hearing Loss in the Elderly, and also for expert resource in the Hearing Loss section for the National Health Survey 2010.

Examples of competitive research grants as primary investigator:

  • Economic Development Board Singapore, Biomedical Sciences POC (Proof of Concept) Grant, $200 000, Oct 2007 – Sept 2008. Development of and Determination of the Efficacy and Safety of a Novel Drug-Eluting Absorbable Stent for Trachea Stenosis.
  • Biomedical Research Council Singapore /ASTAR Award S$197,000 (2005-2009). Genotypic & Phenotypic Correlations of Hereditary Non-Syndr, mic Hearing Loss in Singapore: Connexin 26, Connexin 30, Pendrin & A1555G mutations.Dropper Filling Test Tubes
  • NUS Office of Life Science Grant Start Up Award (2005 – 2008). The Role of Microbes in Non-Allergic Rhinitis and Otitis Media with Effusion in Children. Collaboration with Karonlinska University, Sweden. SGD 100,000.
  • National Research Foundation Collaborative Research Project CRP 8 million SGD Grant – SGD200, 000. Novel Drug Eluting Bioabsorbable Stent for Trachea Stenosis. (Jan 2010-Mar 2012).
  • National Research Foundation, Proof of Concept Grant, June 2010 –30 Nov 2011. Primary Investigator. Development of a novel bioabsorbable ventilation tube for chonic middle ear infection. SGD200,000.
  • Health Service Research CRG, Health Service Development Program Grant, MOH.. Primary Investigator. An Automated Telephone-Administered Hearing Test for Mass Screening of Hearing Loss in Singapore. SGD 973,632,000 .
  • Biomedical Engineering Programme (BEP) POC Grant, ASTAR. SERC grant # 103 1490002. Clinical PI. Office-based Ventilation Tube Applicator for Patients with Otitis Media with Effusion SGD 497,365.
  • Singapore MIT Alliance for Research and Technology SMART Innovation Grant – 1 Dec 2012 –July 2015. A novel biodegradable ventilation tube with sustained drug-eluting property for treatment of middle ear effusion. $250,000
  • BEP-ASTAR POV Grant, SERC . Office-based ventilation tube applicator for patients with otitis media with effusion. Ventilation Tube Application for Patients with Otitis Media with Effusion.1 Sept 2013 – 31 Aug 2015, $1,683,044.
  • MoH Health Service Development Programme HSDP Fund. Community based mobile hearing van service to improve hearing service., June 2014 – May 2016, SGD 4,870,826,

 

Patents

  • Venkatraman SS, Ng AHC, Boey FYC, Lim LHY. A Bioabsorbable Tracheal Stent, And Method of Manufacturing Thereof. Filed 21 March 2012. A Biodegradable Tracheal Stent and Method of Manufacturing Thereof. US Provisional Patent #61/454,858.
  • Provisional Singapore Application: New Invention Disclosure: Title: Apparatus for Office-based Grommet Tube Insertion; ILO Ref: 12235A. A*STAR Grant No: 103 149 0002. 1st Sept 2012.
  • Lynne HY Lim, Gan CW, Chooi WH, Venkatraman SS, Ng AHC, Wong YS. Bio-absorbable Medicament-Eluting Ventilation Tube. Filed 30 Sep 2013 – PCT/SG2013/00042

 

Research Publications

1. Lynne Lim HY. A Decade of Restructuring in the Singapore General Hospital – A Critique. Merit Award for the Essay Competition at the 10th Annual Scientific Meeting. SGH Proceedings, Volume 8, No.2, 1999.

2. Lynne Lim HY, Fei Xun, Low WK, Joseph Wee, Robert Ng TH, Song IC. Tissue culture and transplantation of salivary acinar cells in an animal model -preliminary report. Department of Clinical Research Annual Report 1999, p 45.

3. Lynne Lim HY, Goh YH, Vincent Chong, Chan YM, Low WK. Malignancy of the Temporal Bone and External Auditory Canal. Otolaryngol Head Neck Surg 2000 Jun; 122 (6): 882 – 6.

4. Lynne Lim HY. Why I Choose to Work In This Medical Campus. First Prize Essay Award at SGH Scientific Meeting 2000. SGH Proceedings, Volume 9, No. 2, 2000.

5.Lynne Lim HY, Christopher Goh HK. Renal Cell Carcinoma Metastasis to the Sinonasal Area. ENT Journal 2001 July; 80 (7): 462-467.

6. Lynne Lim HY, Soo KC, Chong YK, Gao F, Hong GS, Lim TH. Well -differentiated Thyroid Carcinoma – Factors predicting recurrence and survival. Singapore Med J 2002; 43(8): 399-402.

7. Lynne HY Lim, JH Greinwald, Jr. Current status of genetics in the evaluation and management of sensorineural hearing loss. Curr Opin Otolaryngol Head Neck Surg 2002, 10:435–439

8. Lynne HY Lim, , JK Bradshaw, YS Guo, V Pilipenko, C Madden, D Ingala, M Keddache, DI Choo, R Wenstrup, RJH Smith, JH Greinwald, Jr. Genotypic and Phenotypic Heterogeneity of DFNB1-related Hearing Impairment in the Midwestern United States. Archives of Otolaryngology, Head and Neck Surgery 2003; 129(8):836-840.

9. Lynne Lim HY, Chao SS, Goh HK, Ng CY, Goh YH, Khin LW. Parotid gland excision – 4 year review of 118 patients. Head and Neck Journal 2003; 25(7): 543-548.

10.Lynne Lim HY, LE Loong, Goh HK, A Balakrishnan, J Wee. Nasopharyngeal Carcinoma in Children. International Journal of Clinical Practice 2003; 57(10): 871-4.

11. Lim CH, Goh YH, Chao SS, Lynne Lim HY. Pseudocyst of the auricle. Laryngoscope 2002; 112: 2033-2036.

12. Greinwald JH, Bradshaw JK, Lim LHY et al. Mutations in the GJB2 gene among Bangladeshi with non-syndromic hearing impairment. American Journal of Human Genetics 71(4); 2121 Suppl. S Oct 2002.

13.Lynne Lim, C Hartnick, JP Willging. Rare Case of Combined Type I and II First Branchial Sinus. J of Pediatr Surg Oct 2003, 38(10): E12-E13.

14.Lynne H. Y. Lim , Manoj Kumar and Charles M. Myer, III Head and neck trauma in hospitalized pediatric patients. Otolaryngology – Head and Neck Surgery, 130 (2), Feb 2004, Pages 255-261.

15. Guo Y, Pilipenko V, Lim LH (Lynne Lim), Dou H, Johnson L, Srisailapathy CR, Ramesh A, Choo DI, Smith RJ, Greinwald JH. Refining the DFNB17 interval in consanguineous Indian families. Mol Biol Rep. 2004 Jun; 31(2):97-105.

16. Lim CH, Goh YH, Chao SS, Lynne Lim HY. Pseudocyst of the auricle: a histologic perspective. Laryngoscope. 2004 Jul; 114(7):1281-4.

17. Lynne HY Lim, Azizkhan RG, Cotton RT , Wood RE, Cohen AP, MJ Rutter. Complications of metallic stents in the pediatric airway. Otolaryngol Head Neck Surgery 2004; 131: 355-61.

18. Preciado DA, Lynne HY Lim, Cohen AP, Madden C, Myer D, Ngo C, Bradshaw JK, Lawson L, Choo DI, Greinwald JH. A diagnostic paradigm for childhood idiopathic sensorineural hearing loss. Otolaryngol Head Neck Surg 2004; 131: 804-9.

20.Lynne Lim, Dou HW, Ali M, Pilipenko V, Bradshaw J, Lin X, Greinwald JHG. Is the GJB2 mutation, V27I/E114G, related to hearing loss? The proceedings of the 28th annual midwinter Research meeting of the Association for Research in Otolaryngology. February 2005.

21. SP Eng, CHK Goh, JBK Khoo, TL Yang, LHY Lim. Metastatic Angiosarcoma to the thyroid. Rev Laryngol Otol Rhinol 2005; 126: 111-4.

22. Lynne HY Lim et al, Jan 2003, The Connexin-deafness Homepage (http://crg.es/deafness/). Non-syndromic deafness mutation in connexins: GJB2 (Cx26). Reported new mutation: L90V GJB2 mutation.

23.Azizkhan RG, Rutter MJ, Cotton RT, Lim LH, Cohen AP, Mason JL. Lymphatic malformation of the tongue base. Jour of Pediatr Surg 2006, 41(7):1279-1284. 23.Lynne HY Lim et al, Jul 2007. The Connexin-deafness Homepage (http://crg.es/deafness/). Non-syndromic deafness mutation in connexins: GJB2 (Cx26). Reported new mutations: I30V, G4D GJB2 mutations.

25.RS Rana, B Tang; L Zhang ; H Garg; DY Wang ; Lynne HY Lim. Reverberation Canceling Wireless Aid for Hearing Impaired. Analog Integrated Circuits and Signal Processing, 2007; 51(3):155-167.

26.Pediatric Hearing Impairment Caregiver Experience: Impact of Duration of Hearing Loss on Parental Stress. Meinzen-Derr J, Lim LH (co-first author), Choo DI, Buyniski S, Wiley S. Int J Pediatr Otorhinolaryngol, 2008 Nov: 72(11):1693-1703.

27.Lynne Lim. A Multidisciplinary Approach to The Management of Congenital Hearing Loss – Program at the Centre for Hearing Intervention and Language Development, National University Hospital Singapore. Annals Academy of Medicine Singapore. Annals Academy of Medicine Singapore; Dec 2008, Suppl 3; 37(12): 57-9.

28.Lynne Lim, Soma Sundram, Xu LiQing. Genotypic and Phenotypic Correlations of Enlarged Vestibular Aqueduct in Children. To Otology Neurotology.

29. Management of Rhinosinusitis and Allergic Rhinitis Clinical Practice Guidelines Dec 2009, Ministry of Health: Section on PEDIATRIC RHINOSINUSITIS.

30. Functional Screening for Elderly Singaporeans – Clinical Practice Guidelines Jan 2010, MOH: Section on HEARING LOSS

31. National Health Survey 2010, Singapore, MOH initiative. Section on Hearing Loss. Published Oct 2011. Epidemiology and Diseases Unit, MoH. Providing training on hearing loss assessment and technical advice on hearing loss definitions, reviewing the chapter on hearing loss and other input.

32. Lynne Hsueh Yee Lim, Jocelynne del Prado,Ling Xiang, Abdul Rahman Bin Yusof , Jenny Hooi Yin Loo. Vibrant Soundbridge middle ear implantations: experience at National University Hospital Singapore. European Archives of Oto-Rhino-Laryngology and Head & Neck, 2012 Sep; 269(9):2137-43.

33. Siow JK, Alshaikh NA, Balakrishnan A, Chan KO, Chao SS, Goh LG, Hwang SY, Lee CY, Leong JL, Lim LHY, Menon A, Sethi A, Tan H, Wang DY, Singapore Ministry of Health. Ministry of Health clinical practice guidelines: Management of Rhinosinusitis and Allergic Rhinitis. Singapore Medical Journal 2010, Mar; 51(3):190-197.

34. Thilagaratnam S, Ding YY, Au Eong KG, Chiam PC, Chow YL, Khoo G, Lim HB, Lim HYL, Lim WS, Lim WY, Peh KC, Phua KT, Sitoh YY, Tan BY, Wong SF, Wong WP, Yee R. Health Promotion Board-Ministry of Health Clinical Practice Guidelines: Functional Screening for Older Adults in the Community. Singapore Medical Journal Jun 2010; 51(6):518-522.

35.Lynne Lim Hsueh Yee, Amilia Wee Li Yan, Ragnar Rylander. Otitis, rhinitis and atopy in relation to domestic endotoxin and beta-glucan exposure among children in Singapore. Environmental Health and Preventive Medicine, Sept 2010; 15(5), 271-275.

36.Idris Nurliza, Lim LHY. Discoloration leading to black eschar over the nose: Invasive Fungal Sinusitis. Journal Pediatric Child Health. 2010 Dec; 46(12):779, 789

37. Lynne Lim HY. The College of Family Physician’s Journal Publication – The Singapore Family Physician for the March skills course. Hearing Section. March 2011.Community Functional Screening Follow Up Resource for Primary Care Doctors March 2011. Chapter 4: hearing. P23-26. SFP2011; Mar 37(2) Supplement.

38. G. H. Zhu, Anthony H. C. Ng, Subbu S. Venkatraman, Freddy Y. C. Boey, Amilia L. Y. Wee, Scott L. Trasti, Lynne H. Y. Lim. A Novel Bioabsorbable Drug-Eluting Tracheal Stent. Laryngoscope 2011, 121, 2234–2239.

39. Nurliza Idris, Lynne Lim HY. Retrospective Review of Grommet Insertions For Otitis Media With Effusion In Children in Singapore. Medical Journal of Malaysia 2011 Aug; 66(3):227-30.

40. Lynne Hsueh Yee LIM, Ling XIANG, J del PRADO, Millo Achille BELTRAME. Simultaneous Vibrant Soundbridge Implantation & 2nd Stage Auricular Reconstruction for Microtia with Aural Atresia. Audiology Research 2011; 1:e28, 9-12.

41.Lynne Lim HY. National Health Survey 2010, Singapore, MOH initiative. Section on Hearing Loss. Published Oct 2011. Epidemiology and Diseases Unit, MoH.

42. Lynne Hsueh Yee Lim, Jocelynne del Prado,Ling Xiang, Abdul Rahman Bin Yusof , Jenny Hooi Yin Loo. Vibrant Soundbridge middle ear implantations: experience at National University Hospital Singapore Ms. No. EAORL-D-11-00934R1. European Archives of Oto-Rhino-Laryngology and Head & Neck, 2012 Sep;269(9):2137-43.

43. Lynne Lim, Somasundaram Subramaniam, Xu LiQing, Chiea-Chuen Khor, Denise Goh, and Yeh Ing Berne. Clinical, Audiometric, Radiologic, and Genetic Profiles of Southeast Asian Children With Hearing Loss Due to Enlarged Vestibular Aqueduct. Otology & Neurotology 2011, 32:1464-1467.

45. Nurliza Idris, Lynne Lim HY. Nasal eschar- a warning sign of potentially fatal invasive fungal sinusitis in immunocompromised children. Journal of Pediatric Hematology Oncology. 2012 May; 34(4):e134-6.

44. Ng AH, Ng NS, Zhu GH, Lim LHY, Venkatraman SS.A fully-degradable tracheal stent: in vitro and in vivo characterization of material degradation. J Biomed Mater Res B Appl Biomater. 2012 Apr;100(3):693-9

45. Er Poi Voon, Tan Kok Kiong, Arun S. Narayanan, Clarence W. de Silva, Lim Hsueh Yee Lynne. Control and Intelligent Systems, Vol. 41, No. 3, 2013, 1. Development of digital Pseudo binaural hearing aid.

46. Techinical: **Tan KK, Liang WY, Phan LP, Huang SN; Clinical: **Lim HYL, Gan CW. 2012. Control Of A 2-DOF Ultrasonic Piezomotor Stage For Grommet Insertion. Mechatronics. Dec 2013, 23(8):1005-1013. (** Joint 1st authors)

47. Gan, CW, WH Chooi, HC Ng, YS Wong, SS Venkatraman and LHY Lim, “Development of a Novel Biodegradable Drug-Eluting Ventilation Tube for Chronic Otitis Media with Effusion”. Laryngoscope, (2013).

48.Jenica Yong, Loh Woei Shyang, Lynne Lim. Annals of Pediatric SURGERY-D-13-00054, entitled “Work Type II First Branchial Cleft Cyst – A Rare Anomaly with a Classical Presentation. March 2014

49. * Kok Kiong Tan ; Wenyu Liang ; Le Phuong Pham ; * Hsueh Yee Lim ; Chee Wee Gan. *1st authors. Publication IEEE, IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM), 2013: 1448 – 1453.

50. Wenchao Gao ; Kok Kiong Tan ; Wenyu Liang ; Chee Wee Gan ; Hsueh Yee Lim. Stereo vision based intelligent system for middle ear treatment . Publication IEEE, IEEE International Conference on Robotics and Biomimetics (ROBIO), 2013: 1426 – 1431.

51. Wenchao Gao ; Kok Kiong Tan ; Wenyu Liang ; Chee Wee Gan ; Hsueh Yee Lim. . IEEE 23rd International Symposium on Industrial Electronics (ISIE), 2014: 1544 – 1549.

52.Lynne HY Lim, Ling Xiang, Naomi YM Lee, Kelvin CP Yuen, Rui Jie Li.Validation of the Paediatric Hearing Impairment Caregiver Experience Questionnaire in the Singapore Population. Ann Acad Med Singapore 2014; Vol. 43 No. 7 July 2014

53.Hear here: Children with hearing loss learn words by listening. Joyce Lew; Alison A Purcell; Maree Doble; Lynne H Lim. International Journal of Paediatric Otorhinolaryngology 78 (2014) 1716–1725

 

Education & Mentorship
  • Lynne has enjoyed teaching widely over the years, for Medical students, ENT trainees, ENT fellows, nurses, Master of Public Health, Master of Clinical Investigation, Change workshop, Mater of Audiology, Master of Speech Language Pathology, School of Design students
  • Examiner for ENT Basic and Advanced Trainees examinations and specialty accreditation
  • Founding Training Advisory Committee for the MSc in Speech and Language Pathology, and MSc in Audiology
  • Residency Advisory Committee Otolaryngology, MOH, 2010 – 2014
  • Workgroup for Joint Examinations with American Board of Medical Specialties (ABMS), Ministry of Health (MOH), 2011-2013
  • Published book chapters on 1. Airway Obstruction, 2. Hearing Loss and 3. Speech and Resonance Disorders in “Ear Nose and Throat Disorders for the General Practitioner”
  • Published book chapter on Common ENT Conditions in “Paediatrics On-The-Go”

Photo 10 Inaugural MSc Audiology Class 2013

With inaugural batch of MSc Audiology program students and staff, Aug 2013

 

As Expert Panel Resource Person

CPG Rhinosinusitis

CPG Functional Screening Hearing Loss Older Adult

  • Itinerant Support Service (ISS) National Workgroup Singapore (2004 – 2006)
  • MoH Review of National Health Service Development Program funding for cochlear implant subsidy (2004 – 2005)
  • Board for Appeal of the Foreign Domestic Worker Levy Concession for Persons with Disabilities. National Council of Social Service, Singapore, 2007 – 2010
  • Cost-effectiveness evaluation of pneumococcal vaccine. Healthcare Performance Group, Clinical Quality Improvement Division, MOH
  • Determination of the minimum standards required for the provision of paediatric ENT services. Workgroup for MoH, Health Services Management. 2008
  • Rhinosinusitis Clinical Practice Guidelines Workgroup 2008, MOH
  • Interventions for the Elderly: Screening for Hearing Loss in the Elderly. Clinical Practice Guidelines Workgroup 2008, MOH
  • Workgroup for Practice guidelines for the Psycho-educational assessments and placements of children with learning and special needs (6-18 years old) 2010, MOH
  • Community Functional Screening Programme Training Manual and Follow up Resource for Primary Care Doctors. Lead for Hearing Health section. 2010 – 2011, Health Promotion Board, MOH
  • Environmental Resources Management Consultancy Study on Noise Impact from Air Traffic Operation around Airports and Airbases in Singapore. 2010, National Environmental Agency
  • Government Subsidies Required For Hearing Aids. 2013, MOH.
  • Functional Screening Technical Workgroup Committee, Health Promotion Board. 2014 – ongoing, MOH